Stem cell treatment of Parkinson's disease
Parkinson's disease
Parkinson's disease is a movement disorder and it is characterized by muscle rigidity, tremor and a slowing of physical movement. This is caused by the degenerative character of the disease, which primarily affects the central nervous system and leads to an impairment of motor and speech skills and a number of other body functions.
Parkinson's disease is usually treated with drugs designed to mask its symptoms, thus helping patients live a more normal life, for a while. But eventually, the drugs become ineffective as the disease worsens. Another treatment that is gaining in popularity is deep brain stimulation; a surgical treatment involving the implantation of a medical device called a brain pacemaker, which sends electrical impulses to specific parts of the brain.
The XCell-Center Parkinson's treatment
The XCell-Center's Parkinson's treatment differs from standard methods because, in contrast to temporarily masking symptoms with drugs or implanted devices, it is a drug-free alternative focused on affecting physical changes in the brain that can improve a patient's quality of life.
In a pilot survey, more than 60% of the Parkinson's patients treated with stem cells at the XCell-Center reported improvements.
Most Parkinson's patients are treated by lumbar puncture; injecting the stem cells into the cerebrospinal fluid which transports them up the spinal canal and into the brain. However, a new procedure, by which the stem cells are surgically implanted directly into the brain, is also available.
Lumbar puncture is an outpatient procedure that requires patients to stay in Germany 4 or 5 nights. Direct surgical implantation is an inpatient procedure that requires patients to stay in Germany for about 10 nights.
Bone Marrow Collection
On the
first day, bone marrow is collected from the patient's iliac crest
(hip bone) using thin-needle mini-puncture under local anesthesia.
Although some pain is felt when the needle is inserted, most
patients do not find the bone marrow collection procedure
particularly painful. The entire procedure normally takes about 30
minutes.
Once the bone marrow collection is complete, patients may return to their hotel and go about normal activities. Patients who receive general anesthesia must lie down for a short recovery period before returning to their hotel.
More detailed information on the bone marrow collection procedure is available in the Bone Marrow Informed Consent document (PDF file).
Laboratory Processing
The next
day, the stem cells are processed from the bone marrow in a
state-of-the-art, government approved (cGMP) laboratory. In the
lab, both the quantity and quality of the stem cells are measured.
These cells have the potential to transform into multiple types of
cells and are capable of regenerating or repairing damaged
tissue.
Stem Cell Implantation
On the third day, the stem cells are implanted back into the patient by lumbar puncture or surgical implantation. Surgical implantation is performed under general anesthesia.
Lumbar Puncture
A spinal needle is inserted between L4 and L5 vertebrae and a small amount of spinal fluid is removed. A portion of that spinal fluid is mixed with the stem cell solution which is then injected into back into the patient's spinal fluid, not the spinal cord. After the stem cells have been implanted, the patient will lie down in the recovery room for a few hours before returning to his or her hotel room. The lumbar puncture procedure is performed under local anesthesia for adults and general anesthesia for children. Under normal circumstances, procedures performed under local anesthesia are not painful.
Surgical Implantation
Prior to surgery,
physical and functional damage will be assessed by computer
tomography (CT), magnetic resonance imaging (MRI) and positron
emission tomography (PET). Once the affected brain regions have
been identified and mapped, the neurosurgeon will implant the stem
cells using a high tech navigation system that allows the cells to
be placed with high accuracy.
All surgical implantation procedures are performed under general anesthesia.
Following Treatment
Patients who are treated by lumbar puncture are required to stay in town on the day after their procedure for general safety purposes. They may return home on the fifth day.
Surgical implantation patients may leave upon discharge from the hospital, usually on the ninth or tenth day, depending upon how their recovery progresses.
Results
75 Patients, nearly 50% of the
total cohort, did complete the clinical evaluation forms. Of these
patients, 36 reported clinical improvements.
The other patients did not notice any clinical change or did mention natural disease progression.
According to 21 of those patients, their physicians did confirm their improvements; five patients were able to decrease and four patients could even fully discontinue their Parkinson's disease related medication.
Most patients reported a decrease of motor parkinsonism (N=29), including rigidity and tremor, resulting in improved speech (N=24), dexterity (N=23), swallowing (N=20), handwriting (N=20), and stability (N=19). Thirty patients also noticed increased motivation and/or initiative.
Click to view or print complete Parkinson's treatment results, including graphs (pdf)
For safety information on 870 patients treated by lumbar puncture, please view our Lumbar Puncture Safety Statistics (PDF file).
In Patients' Own Words
Johannes Wolf - 72 years
old
"…I no longer have any pain and I am completely drug free…"
Aubra
Phillips - 59 years old
"…After the stem cell treatment I would no longer freeze…"
Ted
Ebertsch - 66 years old
"…My neurologist saw me during this time and confirmed that I
looked like I was doing very well…"
Jon
Andresen - 71 years old
"…Now, I am walking like I was before I had Parkinson's…"
Costs
Stem cell implantation via lumbar puncture: 7,995 Euros (adults)
Minimally invasive surgical implantation of stem cells directly into the brain: 25,500 Euros
Evaluation Process
In order to be evaluated for treatment, patients must complete an online medical history form. Once you've completed the online medical history and submitted it, a patient relations consultant will contact you. He or she will assist you with the rest of the evaluation process. Upon treatment approval, your consultant will also assist you with treatment scheduling and trip preparation.
